Multidrug-Resistant Corynebacterium striatum Associated with Increased Use of Parenteral Antimicrobial Drugs
نویسندگان
چکیده
resistant bacteria. We retrospectively identified 179 isolates in a clinical database. Clinical relevance, in vitro susceptibility, and length of parenteral antimicrobial drug use were obtained from patient records. For patients with hardwareor device-associated infections, those with C. striatum infections were matched with patients infected with coagulase-negative staphylococci for case–control analysis. A total of 87 (71%) of 121 isolates were resistant to all oral antimicrobial drugs tested, including penicillin, tetracycline, clindamycin, erythromycin, and ciprofloxacin. When isolated from hardware or devices, C. striatum was pathogenic in 38 Multidrug-Resistant Corynebacterium striatum Associated with Increased Use of Parenteral Antimicrobial Drugs
منابع مشابه
When Good Bugs Go Bad: Epidemiology and Antimicrobial Resistance Profiles of Corynebacterium striatum, an Emerging Multidrug-Resistant, Opportunistic Pathogen.
Infections with Corynebacterium striatum have been described in the literature over the last 2 decades, with the majority being bacteremia, central line infections, and occasionally, endocarditis. In recent years, the frequency of C. striatum infections appears to be increasing; a factor likely contributing to this is the increased ease and accuracy of the identification of Corynebacterium spp....
متن کاملClonal Multidrug-Resistant Corynebacterium striatum Strains, Italy
We assessed the clinical relevance and performed molecular characterization of 36 multidrug-resistant strains of Corynebacterium striatum. Pulsed-field gel electrophoresis confirmed a single clone, possessing erm(X), tetA/B, cmxA/B, and aphA1 genes, but few related subclones. This strain is emerging as a pathogen in Italy.
متن کاملAminoglycoside Resistance in ICUs: Are We Running out of Drugs, for Bad Bugs
Many classes of antibacterial drugs are currently available for physicians to use, however the plan of antibiotic development has slowed during the last decade. The World Health Organization (WHO) has identified antimicrobial resistance as one of the 3 most important problems for human health. Antimicrobial resistance is a growing problem worldwide, especially in hospitals, where resistant orga...
متن کاملAminoglycoside Resistance in ICUs: Are We Running out of Drugs, for Bad Bugs
Many classes of antibacterial drugs are currently available for physicians to use, however the plan of antibiotic development has slowed during the last decade. The World Health Organization (WHO) has identified antimicrobial resistance as one of the 3 most important problems for human health. Antimicrobial resistance is a growing problem worldwide, especially in hospitals, where resistant orga...
متن کاملSusceptibility to Aminoglycosides and Distribution of aph and aac(3)-XI Genes among Corynebacterium striatum Clinical Isolates
Corynebacterium striatum is an opportunistic pathogen, often multidrug-resistant, which has been associated with serious infections in humans. Aminoglycosides are second-line or complementary antibiotics used for the treatment of Corynebacterium infections. We investigated the susceptibility to six aminoglycosides and the molecular mechanisms involved in aminoglycoside resistance in a collectio...
متن کامل